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Lijesen, G

Amino acid activation of mTOR has also been linked to the reduction of toxic effects of some chemotherapeutic agents such as doxorubicin by preventing the doxorubicin-dependent mitochondrial damage and oxidative stress (Tedesco et al., 2020)

Discussion Significance of the study To our knowledge, this is the most comprehensive network meta-analysis comparing the efficacy of SL, IM, and oral routes of administration of vitamin B12 in patients with vitamin B12 deficiency

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Deficiency after gastric banding is therefore primarily related to: Reduced dietary intake and food tolerance , limiting consumption of B12-rich foods Use of acid-suppressing medicines (PPIs or H2RAs) , which can impair the release of B12 from food proteins and reduce absorption of food-bound B12 Crystalline B12 the form found in supplements and fortified foods does not require acid or pepsin for release