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Interestingly, the anti-apoptotic protein Bcl-2 binds to mutant SOD1 and aggregates in spinal cord mitochondria from patients and a mouse model of ALS, suggesting that mutant SOD1 may be toxic by depleting motor neurons of this anti-apoptotic protein (Pasinelli et al., 2004)

AHK-Cu is a copper-binding tripeptide alanine-histidine-lysine complexed with copper(II) and its headline claim is hair growth

It inhibits EMT via endorsing cytoskeleton shrinkage, upregulating E-cadherin activation, and suppressing N-cadherin, snail, and vimentin

The injection is administered intramuscularly, typically in the upper arm or glute, and usually takes just a few seconds

Further preclinical and clinical studies could provide evidence for berberines clinical utility in attenuating secondary brain injury after TBI