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Over time, this results in brighter, more even-toned skin with reduced hyperpigmentation and dark spots

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Furthermore, normal astrocytes expressing mutp53 were able to form spheres, emphasizing the potential of mutp53 in non-stem cells to trigger a CSC-like state (Escoll et al., 2017)

Mathematically, to apply this proration factor we would calculate the ratio between: (1) the ACO's average assigned beneficiary person years for the 2 performance years that constitute BY1 and BY2 for the ACO's current agreement period (regardless of whether these performance years occurred over one or multiple prior agreement periods, which would occur if the ACO early renews immediately before the current agreement period) and (2) the average assigned beneficiary person years in BY1 and BY2 for the ACO's current agreement period calculated using the ACO's certified ACO participant list and assignment methodology for a given performance year within the current agreement period