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Eur J Biochem 261(1):19 Lowther WT, Zhang Y, Sampson PB, Honek JF, Matthews BW (1999) Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues

The causes may be both inadequate intake and inadequate absorption

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But, theyre not for everyone

Folate and vitamin B12 status in Latin America and the Caribbean: an update