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TCA cycle intermediates were undetectable when [ 15 N, 13 C 5 ]valine was used as substrate, likely reflecting the low intrinsic levels of BCAT in the human liver and the further decrease in expression of metabolic genes (including BCAT) known to occur upon plating of hepatocytes

The synthesis of a triglyceride is another application of the ester synthesis reaction

In animals, VC can be synthesized by the organism, acquired through the diet, or both

Luckily, the KD can maintain gut microbiota homeostasis

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