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Nrf2 plays a pivotal role in redox homeostasis and is involved in key metabolic processes, including xenobiotic detoxification, iron and heme metabolism, lipid and carbohydrate metabolism, proteostasis, and the regulation of cell death pathways ( The activity of Nrf2 is primarily regulated by Kelch-like ECH-associated protein 1 (Keap1), a cytosolic repressor that acts as a substrate adaptor for a Cullin-3-based E3 ubiquitin ligase complex

Data availability The source data for the findings of this study are available from the corresponding author upon reasonable request

doi: 10.1016/bs.irn.2023.05.010 183

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J Pharmacol Exp Ther 187:185194 Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB (1973b) Acetaminophen-induced hepatic necrosis