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Validation of candidate genes qRT-PCR Treated cells and organoids were washed with PBS and RNA was isolated with Qiagen RNeasy plus mini Kit (# 74134)

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Then, multiple studies have confirmed that Nrf2 can regulate a host of genes associated with ferroptosis, such as ferroportin (FPN), GPX4, small heterodimer partner (SHP) and peroxisome proliferator-activated receptor (PPAR)[50, 128]

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