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J Clin Endocrinol Metab 98:34023410 Sze L, Bernays RL, Zwimpfer C, Wiesli P, Brndle M, Schmid C (2012) Excessively high soluble klotho in patients with acromegaly

The older related compound, clomiphene citrate, is FDA-approved for female infertility and is widely prescribed off-label for male hypogonadism, providing a substantial body of real-world safety data that informs enclomiphene prescribing decisions