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It should be noted, however, that ALDH1A1, but not CYP2E1, is a downstream target of NRF2, which was found to be activated in untreated GCLM KO mouse liver

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Are animal models needed to discover, develop and test pharmaceutical drugs for humans in the 21st century

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Thus front-loading highly saturated membrane lipids may have the consequence of eliminating or quenching the primary biochemical substrates of ferroptosis

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Compared to free epirubicin and epirubicin-loaded nanoparticles, the in vivo results showed increased survival, reduced cytotoxicity, and improved biocompatibility (99)

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2010 Oct;117(2):515-23

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