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9th Annual Oncology Update: Advances & Controversies

1 GPx4 Overview The GPx4 gene is located at the position of sub-band 3 in the main band 13 of the short arm of chromosome 19 in the human genome and the full length of the GPx4 gene is 2865 bases

Chloramphenicol (Chloromycetin): metabolized by cytochrome P450 to an alkylating metabolite that inactivates cytochrome P450 Other inactivators: Mechanism of Action: -- targeting the heme moiety: Steroids: Ethinyl estradiol (Estinyl) Norethindrone (Aygestin) Spironolactone (Aldactone) Others: Propylthiouracil Ethchlorvynol (Placidyl) Overview: Phase II reactions involve non-microsomal enzymes Reaction types: Conjugation Hydrolysis Oxidation Reduction Location (non-microsomal enzymes): primarily hepatic (liver)