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Synthesis of ROS-sensitive polymers (P3) To a solution of ROS sensitive compound (2,2-(propane-2,2-diylbis(sulfanediyl))bis(ehan-1-ol)) (0.26 g, 1.35 mmol) in anhydrous DMF (5 ml), 1,2,4,5-cyclohexanetetracarboxylic dianhydride (0.31 g, 1.41 mmol) was quickly added into the solution

These strategies have only been used in few thiol-based agents

Accumulated evidence suggests that deficiency or excess of certain trace elements may be associated with risk of chronic diseases including cardiovascular diseases, diabetes and cancer

Concomitantly, we measured increased pyruvate levels in mutant compared to control cells (Supplementary Fig

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