cagrilintide with reta

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Continuous activation of c-Met receptors without recovery periods may lead to receptor internalization and reduced surface expressiona protective mechanism cells employ when signaling pathways are overstimulated

Clinical Trial Outcomes with Monotherapy The REDEFINE 1 trial demonstrated that cagrilintide monotherapy at the 4.5 mg maintenance dose produced mean body weight reductions of approximately 10.8% from baseline after 32 weeks of treatment [4]