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Clinically, BAL and sputum profiling demonstrates utility in COPD management: First, MUC5AC, CC16, and EV-related proteins serve as diagnostic/prognostic biomarkers

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Its multifactorial etiology implies the use of a multimodal approach that includes a mix of different topical treatments targeting the melanin synthesis pathways, the anti-inflammatory environment, senescence and vascularity, along with avoidance of exacerbating factors, such as UV light and hormonal contraception

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