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[5] Adult males with an adrenomyeloneuropathy presentation typically present initially with muscle stiffness, paraparesis and sexual dysfunction

Curcumin induced CYP3A4 in multiple models, including HepG2 cells ( Curcumin may reduce CYP19A1 expression levels by suppressing ERR, a mechanism independent of ATZ As previously mentioned, CYP19A1 plays a critical role in the last step of estradiol biosynthesis

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8 Animal models In vitro and in vivo studies have been conducted using small and large animal models of rodents (such as mice and rats), rabbits