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9 BaranovaH.BothorishvilliR.CanisM.AlbuissonE.PerriotS.GlowaczowerE.et al (1997)

whereas digestible carbohydrates, dietary lipids (especially for hydrophobic polyphenols, e.g., curcumin), and additional antioxidants may enhance polyphenol availability Likewise, after epithelial uptake, polyphenols such as flavonoids may diminish phase II metabolism and excretion to enhance polyphenol bioavailability, whereas various polyphenols may act synergistically due to their influence on efflux transporters such as p-glycoprotein [597]

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Because PT-141 activates melanocortin receptors (which also influence melanin production), some patients may notice mild skin darkening with repeated use