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Mohan R , Yi PH, Hansen EN

Cancer Res Treat 53:685694

Large-scale and long-term clinical trials are essential to resolve these concerns

This activation initiates a signaling cascade that turns on Protein Kinase C (PKC) and Mitogen-Activated Protein Kinases (MAPKs), which dynamically stabilize the actomyosin ring, pulling the tight junction proteins firmly back into place and sealing the paracellular gaps