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Another method employed tetramethylpyrazine (TMP), an alkaloid derived from Ligusticum chuanxiong Hort, integrated into a hydrogel composed of Bletilla striata polysaccharide (BSP) and hyaluronic acid (HA) (TMP-BSP-HA), which facilitated inflammation reduction, neovascularization, and collagen deposition in streptozocin-induced diabetic mice, markedly enhancing wound healing in comparison to commercial carboxymethylcellulose-based dressings [136]