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ABACUS topology is wrong (in c), see citation from original article Fig 3a: The overall domain order of ABACUS1 is N-terminusedCitrineattB1ABI1aidL52PYL1attB2edCeruleanC-terminus.

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"Comprehensive methylome characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at single-base resolution"

The rich polar and acidic amino acids in the L2 and L4 regions of hTYR stabilize arbutin in this area, allowing it to successfully chelate with copper ions