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Studies suggest its fat-metabolism effects are not directly mediated via 3-adrenergic receptors, though it may increase 3-receptor expression, potentially improving lipolytic sensitivity over time

Infliximab may take a few days up to two to six weeks for the effects to begin after the first treatment

The main rationale for cycling rather than continuous use involves conservative safety practices given limited long-term human data, cost management, and theoretical concerns about receptor desensitization with extended exposure

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