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Description

In addition, we developed and verified a physiologically based pharmacokinetic (PBPK) model for the endogenous hormone cortisol (hydrocortisone) in healthy adults and children and in adults with adrenal insufficiency using data from an immediate-release formulation of hydrocortisone, Alkindi (Diurnal Ltd, Cardiff, UK), which we had formulated to provide accurate dosing in children [13]

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