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The D-Ala substitution provides dual benefits: modest intrinsic potency enhancement (3-fold in vitro) plus substantial protection against dipeptidylpeptidase IV (DPP-IV) degradation, which normally cleaves between positions 2 and 3

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The structural comparison indicates that the GHSR-G i complex in our structures resembles the canonical NTSR1-G i state with a similar G i interaction profile (Fig

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By helping to manage the cortisol load on the body, the peptide stack helps protect the endocrine system from the suppressive effects of chronic stress, allowing the HPTA to function without that constant biochemical interference