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All of the animal studies were conducted on diabetic rats, including three studies on type 1 diabetic rats and six studies on type 2 [17,18,19,20,21,22,23,24,25]

10.1016/S0098-2997(03)00013-X 209

In addition to reducing NO release and impairing vasodilation, RhoA/ROCK pathway regulates the vascular endothelium of the CC by modulating endothelial cell contraction and disrupting endothelial barrier function