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Coadministration of PIFELTRO with efavirenz, etravirine, or nevirapine is not recommended

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However, efficient extravasation also requires remodeling of the endothelium, a process that occurs at higher blood flow velocities and involves the engulfment of tumor cells by endothelial cells [229]

If untreated, this can progress to more severe symptoms like heart palpitations, pale skin, shortness of breath and even irreversible neurological problems like numbness or tingling, muscle weakness, and mental problems like depression, memory loss, or behavioural changes