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5 Conclusions 1) This retrospective study provides the first in vivo evidence that DARA monotherapy, beyond its cytotoxic effects, modulates the secondary enzymatic functions of CD38 in MM, altering ADO and INO production and supporting a model of antibody-driven purinergic remodeling

Appl Microbiol 117 , 286301 (2014)

IV daratumumab was demonstrated in RRMM patients for monotherapy in the Phase III COLUMBA trial ( 3 prior lines) and in standard combination regimens in the Phase II PLEIADES trial ( 1 prior lines) [14]