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It has been demonstrated that acetylation of some lysine of CAC inhibits the uptake of carnitine into mitochondria and hence negatively affect FAO (Figure 2), is activated by acetylation (Palmieri et al., 2015)

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[11] [12] [84] In February 2026, a French man, Jean-Marc Laurent, filed what has been described as the first legal complaint related to paternal exposure to valproate, alleging that his child developed neurodevelopmental disorders after he had been treated with the drug prior to conception

Patients should be monitored closely for appearance of these symptoms