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In CGD mouse models, the cognitive defect is reproduced even if the animals are kept under specific pathogen-free conditions [34]

Black cumin and TQ were shown to confer neuroprotection and improved disease outcomes in AD animal models

Notably, NPCs from ASD-DM exhibited a greater number of differentially expressed genes (DEGs) compared to TD-N (204 downregulated, 174 upregulated) relative to ASD-N (86 genes downregulated, 88 genes upregulated) (Supplementary Figure 3A-C), indicating a more pronounced transcriptomic shift in the ASD-DM neurophenotype