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For additional information regarding the use of old work time values that were established many years ago and have not since been reviewed in our methodology, we refer readers to our discussion of the subject in the CY 2017 PFS final rule (81 FR 80273 through 80274)

Additionally, CCL2, a neutrophil chemokine implicated in angiogenesis and the pathological changes of psoriatic lesions [24], was markedly elevated in psoriasis-induced mice