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In addition, the interaction between tumor metabolism and the acidic microenvironment is bidirectional, as lower pH inhibits enzymes involved in glycolysis (such as phosphofructokinase-1) and may inhibit tumor cell proliferation and survival (112)

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During this process, ATP is broken down into adenosine diphosphate (ADP) and inorganic phosphate (P i )

It has gained significant attention for its profound effects on connective tissue healing

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