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The N-terminal domain is the GSH-binding site (G-site)

And yes, it supports the use of fatty acids to be burned as energy.(7)

Neuron 110, 34583483

Erastin, one of the earliest discovered ferroptosis inducers, is a small molecule that inhibits the cysteine/glutamate antiporter system [36]

Beside modulation in HMGR expression, the authors also found a decreased expression of Peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) at 1 week after tumor inoculation (Rosa-Caldwell et al., 2019)