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Factors like poor diet, environmental stress, lack of sleep, and UV exposure can further deplete these levels

doi:10.1182/blood-2016-10-569186 17

IGF-1R is a receptor tyrosine kinase expressed broadly across muscle, fat, liver, and other tissues

Key inclusion criteria included a diagnosis of severe AH per NIAAA criteria and severe AKI defined as uremia, metabolic acidosis, creatinine 4 mg/dL, or requiring RRT (ICA grade 3 criteria)