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Persimmon-derived tannin ameliorates the pathogenesis of ulcerative colitis in a murine model through inhibition of the inflammatory response and alteration of microbiota

showed that a high fat diet administered to C57BL/6 mice altered gene expression and rhythmicity of Bmal1 , Clock , Per2, Ppar, Sirt1 , and lipogenesis genes such as Acc1, Fas and Srebp-1c in the liver [44]