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Key takeaways You cant directly equate B12 pills to B12 shots because your body absorbs them differently

It's essential to approach anecdotal evidence with caution, recognizing the individual variability in treatment outcomes

& Paulmurugan, R

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

In cases of compromised stomach functioning, B12-fortified foods and/or B12 supplements allow for better absorption of this nutrient