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Spaulding SW, Burrow GN, Bermudez F, Himmelhoch JM

A predominant precursor of TMA is L-carnitine, which can be converted into TMA by carnitine oxidoreductase or to other precursors that lead to TMA as shown below

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In an open-label RCT ( n = 96), oral administration of melatonin tablets (3 mg/d, 1 h before sleep, for 7 days) with standard treatment, substantially improved sleep quality and blood O 2 saturation parameters in hospitalized COVID-19 patients 667