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Here are some of the main culprits behind low glutathione: Chronic Stress: Constant stress elevates cortisol levels aka the stress hormone. While cortisol helps manage stress, excessive amounts increase oxidative stress, leading to glutathione depletion as it works to protect cells from damage

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Redundancy in the antioxidant defense enzymes provides additional protection against harmful peroxides and, therefore, animals lacking either catalase or GPx-1 appear normal [140, 141]

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