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Endothelial ion transporters, including the Na-H and Na-K-Cl cotransporter, become dysregulated upon neuronal injury, resulting in an imbalance of ionic gradients and cytotoxic edema that contribute to secondary neuronal damage (Pinheiro et al., 2016)

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Parasites, Lyme, EBV and co-infections have been shown to damage gut nerves, trigger autoimmune attacks on nerve cells, suppress vagus nerve functioning and cause chronic inflammation