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The first time damaged mitochondria were linked to PD was through post-mortem studies on individuals who developed the condition after injecting themselves with synthetic heroin contaminated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

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Preclinical studies establish four major neural mechanisms involved in this bidirectional neural signaling include (i) Afferent vagal TRPV1 signaling triggered by inflammatory mediators in airways leading to the release of neuropeptides (NPs) in brainstem

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In particular examples, the modified FXa polypeptides are FX polypeptides that contain a light chain having the sequence of amino acids 1-139 shown in ID n : 134 (ie, corresponding to amino acids 1-139 of any of the SEQ ID NOS: 136-265), or a light chain having an amino acid sequence that is at least 75%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91% , 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more sequence identity with amino acids 1-139 shown in any of SEQ ID NOS: 134

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