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An encouraging strategy involves the development of small molecule inhibitors or alternative therapeutic agents that directly target FSP1, consequently augmenting the susceptibility of tumor cells to GPX4 inhibitors [252]

The superoxide anion is the first step in the process

Recent studies have shown that certain natural products can restore drug-resistant tumor cells sensitivity to ACDs by inhibiting anti-apoptotic signals

Mushrooms, in this case, white-rot fungi such as Ganoderma, Pleurotus , and Trametes , play an integral role in the conversion of biofuels by releasing ligninolytic enzymes (e.g., laccase, lignin peroxidase, and manganese peroxidase) which efficiently depolymerize recalcitrant plant polymers to fermentable sugars (El-Ramady et al., 2022)

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