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Histological analyses described increased fibroblast density, improved collagen alignment and local neovascularization

Also, two of 12 participants had an 80% improvement of symptoms, with most of their symptoms resolved

the solid oral pharmaceutical composition according to any one of items 1 , 2, 8 and 9, wherein the copolymer (A) in the first coating comprises ethyl acrylate repeating units, methyl methacrylate repeating units, and 2-(trimethylammonio)ethyl methacrylate chloride repeating units in a molar ratio of 1 :2:0.1 or 1 :2:0.2

Weeks 8 to 16: Measurable increases in skin thickness and collagen density (supported by clinical data for topical use)