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However, the foundational mechanism paper (Benoist et al., 2014 in J Pharmacol Exp Ther) establishing Dihexas HGF/c-Met pathway activation was formally retracted in April 2025 after being flagged since 2021

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But the most significant outcomes in peptide therapy come from combining peptides that target complementary biological pathways creating synergistic effects that exceed what any single peptide achieves alone

Researchers are increasingly exploring its applications in fields ranging from neuroscience to integrative medicine