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However, clinical trial results are not so satisfactory due to difficulties in targeted delivery to diseased tissues and the potential disruption of ROS-associated physiological signaling pathways [270]

Figure 1 Cytochrome P450-Mediated Metabolic Activation APAP metabolic activation is mainly catalyzed by the cytochrome P450 enzyme and the reactive metabolite associated with hepatotoxicity is commonly considered to be NAPQI (Streeter et al., 1984)