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In both humans and experimental animals, all retinal cell types known to be affected by diabetes contain aldose reductase (AR), the first and rate-limiting enzyme of the pathway

Since most choline in the body and brain are in the form of phosphatidylcholine, it serves as a reservoir or pool for choline

Importantly, the magnitude of these benefits depends on capsaicin dose, exposure duration, and the hosts baseline microbiota composition

PMC 4330071

I genuinely wanted to understand what their reasoning was so I could present a balanced view and write a paragraph or two about it in a blog post to raise awareness and help others advocate for themselves