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Hyon, S

doi: 10.1126/sciadv.aba4353 100 McHughJ

As for the more general TKIs the sequence homology between IGF-1R and IR-A/B kinase domains presented a major problem and therefore side effects were of great concern ( The IGF-signalling system has long been an area of therapeutic interest in the treatment of breast cancer which was further supported by the findings of both the European Prospective Investigation into Cancer and Nutrition (clinicaltrials.gov database