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These findings offer epidemiological support for lifestyle-based interventions that target both movement and micronutrient sufficiency to delay age-related physiological decline ( In contrast, the DO-HEALTH randomized clinical trial, which enrolled over 2,150 older adults across Europe (mean age of 75 years), tested a combination of vitamin D3 supplementation (2000 IU/day), omega-3 fatty acids (1 g/day), and a strength-training program over a three-year period

Numerous studies have shown that various environmental factors, such as dietary patterns, lifestyle habits, and environmental pollution, significantly affect the risk of IBD onset and its clinical manifestations

Previous studies have shown that downregulation of miR-34a affects HDAC activity and the NF-B pathway, which may be closely related to B-cell proliferation and differentiation [163, 164]

Leske et al., 1997), glutamate excitotoxicity (Dreyer, 1998

Elsevier, Amsterdam, pp 6177 Sadef Y, Javed T, Javed R et al (2022) Nutritional status, antioxidant activity and total phenolic content of different fruits and vegetables peels