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Therefore, more researches are necessary to reveal the acting mechanism of NNMT in obesity and T2D and to develop therapeutics targeting NNMT

The repurposed drugs can generally be made immediately available for use in clinical trials as they have known safety profiles at the licensed doses

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The rationale for these modifications is rooted in a practical challenge: tetrapeptides like Epithalon are rapidly degraded by aminopeptidases and carboxypeptidases in experimental systems, limiting the duration of exposure in research protocols