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The clinical translation of nanomedicine-based PCD therapies necessitates rigorous research, development, and collaborative effort to ensure accessibility and benefits for all cancer patients, raising several critical questions

When COMT is slow, more 4-OHE2 remains available for oxidation to reactive quinones increasing demand on GSTM1/GSTT1 glutathione conjugation at exactly the point where their absence is most consequential

Iron overload may not be a central driver of ferroptosis in these disorders, which challenges current assumptions about the physiological triggers of ferroptosis in vivo [35]

Stroke 50 , 28352841 (2019)

(4) Despite various strategies proposed to enhance curcumins bioavailability and therapeutic efficacy, the in vitro - in vivo correlation of cell cytotoxicity and bioavailability remains poorly understood, warranting additional human studies