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12 Brain imaging studies have shown central sensitization in fibromyalgia patients is associated with alterations in brain structure, neurotransmitter function, and patterns of brain activity at rest and when exposed to experimental pain

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The interaction between thyroid hormones and nuclear receptors influences a wide array of physiological processes: Metabolism and digestive system: thyroid hormones increase the basal metabolic rate by enhancing mitochondrial activity and oxygen consumption

Both drug classes share a similar digestive side effect profile as the body adjusts, a pattern noted in the Obesity Medicine Association comparison of the two medications