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What remains unclear is whether the changes observed within the tight junctions in cases of IBD are causal leading to further barrier dysfunction and abnormal immune responses, or the alterations in the function of tight junctions are related to the inflammation itself [101]

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Fifty units of (Speywood) botulinum toxin type A (Dysport) were subcutaneously injected in eight points distributed mostly along V2 in the lateral periorbital area and in three injection points in the inferolateral area taking care not to infiltrate too much directly under the eye to minimise potential aesthetic side effects