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Glutamine suppresses several inflammatory signaling pathways, including suppressing nuclear factor-B (NFB) signaling pathway [26] and signal transducer and activator of transcription (STAT) pathways [27], by increasing the expression of cellular HSPs such as HSP25 and HSP70 [28] and inhibition of the expression of IL-8 which activates and stimulates the migration of neutrophils to inflammatory sites [29]

Pneumonitis Inflammation of the lungs is the most common lung toxicity among patients receiving ICIs, with an estimated overall incidence of 2.7% to 5%

Individuals with gluten and dairy allergies

At least for ritonavir-treated human intestinal carcinoma cells, an upregulation of Mrp1 expression and activity after chronic exposure to ritonavir has been reported [94]

Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition