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Volcano plot analysis was conducted using the R-based EnhancedVolcano (v1.14.0) package ( The included volcano plot analysis was filtered for P values 4 immuno-gold particles (white arrows) in patient-derived SU-DIPG-VI cells xenografted to the hippocampus

Nat Rev Dis Primers 2016;2:16080

Valentov K, Stejskal D, Bartek J, Dvorckov S, Kren V, Ulrichov J, Simnek V

Importantly, the underlying cell death mechanism is triggered by CBS inhibition in HepG2 cells via ferroptosis, suggesting that CBS has a previously unreported function in this process