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5.3 The gut barriersystemic inflammation axis: a common convergence endpoint and mechanistic landing point across modules 5.3.1 Module positioning: why it serves as a common endpoint For the functional outputs of different metabolic modules to influence synovial inflammation and structural damage, they likely traverse a common conduit: Gut Barrier Permeability AlterationSystemic Inflammation AmplificationPeripheral Immune Activation. (Liu et al., 2018)

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Because of the risks of corporal rupture or other serious penile injury, XIAFLEX is available for the treatment of Peyronies disease only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the XIAFLEX REMS Program